HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Cyclopropoxyphenyl)boronic acid → 3-Chloro-1-(4-cyclopropoxyphenyl)-5-(5-trifluoromethylpyrid-2-yl)-1H-indole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Cyclopropoxyphenyl)boronic acid | HCID 53216708 | — |
| Reactant | 3-chloro-5-(5-trifluoromethylpyrid-2-yl)-1H-indole-2-carboxylic acid ethyl ester | HCID 68473534 | — |
| Product | 3-Chloro-1-(4-cyclopropoxyphenyl)-5-(5-trifluoromethylpyrid-2-yl)-1H-indole-2-carboxylic acid | HCID 68698059 | — |
Reaction Steps
The title compound was prepared in accordance with Example 8(c) from 3-chloro-5-(5-trifluoromethylpyrid-2-yl)-1H-indole-2-carboxylic acid ethyl ester (see Example 36(a)) and 4-cyclopropoxyphenylboronic acid (see Example 40(a)), followed by ester hydrolysis in accordance with Example 1(c).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07705023B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-9b785d09f13d426795b40fe512ddd912 |
| Source note | uspto-grants-2010_04 |