2-Chloro-5-propylpyrimidine → 3-Chloro-1-(4-isopropoxyphenyl)-5-(5-propylpyrimidin-2-yl)-1H-indole-2-carboxylic acid
Reaction equation
C([O:3][C:4]([C:6]1[N:7]([C:25]2[CH:30]=[CH:29][C:28]([O:31][CH:32]([CH3:34])[CH3:33])=[CH:27][CH:26]=2)[C:8]2[C:13]([C:14]=1[Cl:15])=[CH:12][C:11](B1OC(C)(C)C(C)(C)O1)=[CH:10][CH:9]=2)=[O:5])C.Cl[C:36]1[N:41]=[CH:40][C:39]([CH2:42][CH2:43][CH3:44])=[CH:38][N:37]=1>>[Cl:15][C:14]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:36]3[N:41]=[CH:40][C:39]([CH2:42][CH2:43][CH3:44])=[CH:38][N:37]=3)[CH:12]=2)[N:7]([C:25]2[CH:26]=[CH:27][C:28]([O:31][CH:32]([CH3:34])[CH3:33])=[CH:29][CH:30]=2)[C:6]=1[C:4]([OH:3])=[O:5]Participants
3
Procedure
The title compound was prepared in accordance with Example 35, Method 1, step (d) from 3-chloro-1-(4-isopropoxyphenyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indole-2-carboxylic acid ethyl ester (see Example 35, Method 1, step (c)) and 2-chloro-5-propylpyrimidine, followed by ester hydrolysis in accordance with Example 1(c).
Sources & evidence
- ORD record
- ord-4e3ec45fd8f044bf8ff9f04975f802f4
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07705023B2
Reaction notes
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