(4-(Cyclopentyloxy)phenyl)boronic acid → 5-Bromo-3-chloro-1-(4-cyclopentyloxyphenyl)indole-2-carboxylic acid ethyl ester

HRID 646164Notes

Reaction equation

HRID 646164 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([C:14]=1[Cl:15])=[CH:12][C:11]([Br:16])=[CH:10][CH:9]=2)=[O:5])[CH3:2].[CH:17]1([O:22][C:23]2[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=2)[CH2:21][CH2:20][CH2:19][CH2:18]1>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([C:26]2[CH:27]=[CH:28][C:23]([O:22][CH:17]3[CH2:21][CH2:20][CH2:19][CH2:18]3)=[CH:24][CH:25]=2)[C:8]2[C:13]([C:14]=1[Cl:15])=[CH:12][C:11]([Br:16])=[CH:10][CH:9]=2)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 23005412(4-(Cyclopentyloxy)phenyl)boronic acidHCID 28330549ethyl 5-bromo-3-chloro-1H-indole-2-carboxylate

Product 1

HCID 686947875-Bromo-3-chloro-1-(4-cyclopentyloxyphenyl)indole-2-carboxylic acid ethyl ester

Procedure

The sub-title compound was prepared in accordance with the procedure described in Example 8(c) using 5-bromo-3-chloro-1H-indole-2-carboxylic acid ethyl ester (see Example 3)5, Method 1, step (a)) and 4-cyclopentoxyphenylboronic acid instead of 4-isopropoxyphenylboronic acid.

Sources & evidence

ORD record
ord-219f9106aef243439b0a979a77840710
Source dataset
uspto-grants-2010_04
Patent number
US07705023B2

Reaction notes

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