反应详情

21.56 g of 4-(2,4-dichlorophenoxy)-3-hydroxybenzonitrile, 14.2 g of chloroacetone, 12.8 g of potassium carbonate and 170 mg of potassium iodide are dissolved in 300 ml of acetone and boiled under reflux for 5 h. After cooling, the precipitate is filtered, concentrated by evaporation, redissolved in ethylacetate and washed with a 1N aqueous solution of sodium hydroxide, water, a 1N aqueous solution of hydrogen chloride and finally with brine. The organic phase is dried over magnesium sulfate and evaporated. The residue is recrystallized from ethylacetate/hexane to yield 4-(2,4-dichlorophenoxy)-3-(2-oxopropoxy)-benzonitrile.

1. temperatureunder reflux for 5 h
2. temperatureAfter cooling
3. filtrationthe precipitate is filtered
4. concentrationconcentrated by evaporation
5. dissolutionredissolved in ethylacetate
6. washwashed with a 1N aqueous solution of sodium hydroxide, water
7. dry with materialThe organic phase is dried over magnesium sulfate
8. customevaporated
9. customThe residue is recrystallized from ethylacetate/hexane