Hydrochloric Acid → HCID 68580059, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl N-(4-chlorophenyl)-4-methoxyisophthalamate (11.8 g) obtained in step A was dissolved in 200 mL of methanol and 60-mL of a 20% aqueous solution of potassium hydroxide. The resulting solution was stirred for 30 minutes at 80° C., and then cooled to room temperature. One M hydrochloric acid was used to adjust the solution to pH of about 3. Then, the resulting precipitate was separated by filtration, washed with water, and dried over calcium chloride under reduced pressure, thereby obtaining 10.7 g (99%) of N=(4-chlorophenyl)-4-methoxyisophthalic acid.

Provenance & Evidence