Hydrochloric Acid → HCID 68580059, compound

HRID 646290Notes

Reaction equation

HRID 646290 reaction equation
ClC1C=CC(N[C:9](=[O:23])[C:10]2[CH:11]=[C:12]([CH:18]=[CH:19][C:20]=2[O:21][CH3:22])[C:13]([O:15]CC)=[O:14])=CC=1.[OH-:24].[K+].[ClH:26]>CO>[Cl:26][C:10]1[CH:11]=[CH:12][C:18]([C:11]2[C:10]([C:9]([OH:23])=[O:24])=[C:20]([O:21][CH3:22])[CH:19]=[CH:18][C:12]=2[C:13]([OH:15])=[O:14])=[CH:19][CH:20]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 23141453HCID 23141453, compound

Product 1

HCID 68580059HCID 68580059, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

Ethyl N-(4-chlorophenyl)-4-methoxyisophthalamate (11.8 g) obtained in step A was dissolved in 200 mL of methanol and 60-mL of a 20% aqueous solution of potassium hydroxide. The resulting solution was stirred for 30 minutes at 80° C., and then cooled to room temperature. One M hydrochloric acid was used to adjust the solution to pH of about 3. Then, the resulting precipitate was separated by filtration, washed with water, and dried over calcium chloride under reduced pressure, thereby obtaining 10.7 g (99%) of N=(4-chlorophenyl)-4-methoxyisophthalic acid.

Workup

  1. temperaturecooled to room temperature
  2. customThen, the resulting precipitate was separated by filtration
  3. washwashed with water
  4. dry with materialdried over calcium chloride under reduced pressure

Sources & evidence

ORD record
ord-d8f1979ae9fb46c3ba01c22c4f8e2746
Source dataset
uspto-grants-2010_04
Patent number
US07705053B2

Reaction notes

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