反应详情

温度

80 °C

Ethyl 4-methoxy-3-[(E)-2-(4-trifluoromethoxyphenyl)vinyl]benzoate (4.5 g) obtained in step A was dissolved in 40 mL of methanol, and 16 mL of a 20% aqueous solution of potassium hydroxide was added. The resulting solution was stirred for 2 hours at 80° C., and then cooled to room temperature. The reaction mixture was adjusted to pH of about 3 with the use of 60 mL of 1 M hydrochloric acid. The resulting precipitate was separated by filtration, washed with water, and then dried over diphosphorus pentoxide under reduced pressure to obtain 4.1 g (99%) of 4-methoxy-3-[(E)-2-(4-trifluoromethoxyphenyl)vinyl]benzoic acid.

1. temperaturecooled to room temperature
2. customThe resulting precipitate was separated by filtration
3. washwashed with water
4. dry with materialdried over diphosphorus pentoxide under reduced pressure