3-Amino-1,2-propanediol → N-(2,3-dihydroxy-propyl)-4-methoxy-3-[(E)-2-(4-trifluoromethylphenyl)vinyl]benzamide

HRID 646378Notes

Reaction equation

HRID 646378 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][C:4]=1/[CH:12]=[CH:13]/[C:14]1[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=1.[NH2:24][CH2:25][CH:26]([OH:29])[CH2:27][OH:28]>>[OH:29][CH:26]([CH2:27][OH:28])[CH2:25][NH:24][C:7](=[O:8])[C:6]1[CH:10]=[CH:11][C:3]([O:2][CH3:1])=[C:4](/[CH:12]=[CH:13]/[C:14]2[CH:15]=[CH:16][C:17]([C:20]([F:21])([F:22])[F:23])=[CH:18][CH:19]=2)[CH:5]=1

Participants

3

Reactant 2

HCID 735613-Amino-1,2-propanediolHCID 231414894-methoxy-3-[(E)-2-(4-trifluoromethylphenyl)vinyl]benzoic acid

Product 1

HCID 23141417N-(2,3-dihydroxy-propyl)-4-methoxy-3-[(E)-2-(4-trifluoromethylphenyl)vinyl]benzamide

Procedure

The captioned compound was synthesized from 4-methoxy-3-[(E)-2-(4-trifluoromethylphenyl)vinyl]benzoic acid obtained in step A of Example 2-2-38 and 3-amino-1,2-propanediol in accordance with the same procedure as in the methods described in step C of Example 1-2-3.

Sources & evidence

ORD record
ord-c14e5f796bee49bd94e01cddf4847b86
Source dataset
uspto-grants-2010_04
Patent number
US07705053B2

Reaction notes

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