(5-Bromothiophen-2-yl)(piperidin-1-yl)methanone → [2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-{4-[5-(piperidine-1-carbonyl)-thiophen-2-yl]-phenyl}-methanone

Participants

Reaction Steps

The title compound is prepared in a manner substantially analogous to General Procedure A using [2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone (550 mg, 1.4 mmol) and (5-Bromo-thiophen-2-yl)-piperidin-1-yl-methanone (CAS 626242-11-3) (315 mg, 1.2 mmol) to give 260 mg (48% yield). MS (ES+) 466.2 (M+H)+

Provenance & Evidence