2-Bromo-1-methyl-1H-imidazole → [4-(1-Methyl-1H-imidazol-2-yl)-phenyl]-[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone

Participants

Role	Name	HCID	Charge
Reactant	2-Bromo-1-methyl-1H-imidazole	HCID 2773262	—
Reactant	[2-(S)-(2-(R)-Methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone	HCID 57980025	—
Product	[4-(1-Methyl-1H-imidazol-2-yl)-phenyl]-[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone	HCID 59264668	11%

Reaction Steps

The title compound is prepared in a manner substantially analogous to General Procedure A using [2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone (439 mg, 1.1 mmol) and 2-Bromo-1-methyl-1H-imidazole (CAS 16681-59-7) (161 mg, 1.0 mmol) to give 39 mg (11% yield). MS (ES+) 353.2 (M+H)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07705025B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-c2b4016ba2cc4303b84090f3e7a050bd
Source note	uspto-grants-2010_04