反应详情

温度

47.5 °C

Benzyl carvedilol (205 g) obtained in step 3 was charged to ethyl acetate (2400 ml) and water (240 ml). The contents were stirred and 10% palladium on carbon (20 g) was added at room temperature. Hydrogen gas was bubbled at room temperature. The temperature was raised to 45-50° C. and bubbling was continued for 8 hours. The reaction mass was filtered to remove the catalyst and the filtrate was concentrated to remove solvent (about 2 L). The contents were chilled to 15-20° C., filtered and washed with chilled ethyl acetate (50 ml) to give carvedilol (140 g) (84%).

1. customHydrogen gas was bubbled at room temperature
2. custombubbling
3. filtrationThe reaction mass was filtered
4. customto remove the catalyst
5. concentrationthe filtrate was concentrated
6. customto remove solvent (about 2 L)
7. temperatureThe contents were chilled to 15-20° C.
8. filtrationfiltered
9. washwashed with chilled ethyl acetate (50 ml)