反应详情

An ice-cooled solution of 50 g of methyl 3-amino-6-bromo-pyrazine-2-carboxylate in 500 mL of MeOH was saturated with methylamine gas. The reaction was then heated at 85° C. in a sealed, stainless steel Parr pressure vessel for 2 h, and cooled to room temperature, and then on an ice water bath. The mixture was concentrated to an oil on a rotary evaporator under reduced pressure. The crude oil was dissolved in EtOAc and washed with water, dried (Na2SO4), filtered, and concentrated to give 43.9 g (88.0% yield) of product as a solid.

1. concentrationThe mixture was concentrated to an oil on a rotary evaporator under reduced pressure
2. dissolutionThe crude oil was dissolved in EtOAc
3. washwashed with water
4. dry with materialdried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated