m-Bromobenzenesulphonyl chloride → HCID 41647239, compound

HRID 646707Notes

Reaction equation

HRID 646707 reaction equation
[NH2:1][C@@H:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.[Br:11][C:12]1[CH:13]=[C:14]([S:18](Cl)(=[O:20])=[O:19])[CH:15]=[CH:16][CH:17]=1>>[Br:11][C:12]1[CH:13]=[C:14]([S:18]([NH:1][C@@H:2]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:4][CH2:3]2)(=[O:20])=[O:19])[CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 17943m-Bromobenzenesulphonyl chlorideHCID 70000841-Aminoindane, (S)-

Product 1

HCID 41647239HCID 41647239, compoundYield 52%

Procedure

3-bromo-N-[(1S)-2,3-dihydro-1H-indene-1-yl]benzenesulfonamide was synthesized according to the procedure described above from (S)-1-aminoindan and 3-bromobenzensulfonyl chloride. Yield 52%. 1H NMR (400 MHz, CDCl3): 7.20 (m, 1H), 7.90 (dd, 1H), 7.80 (dd, 1H), 7.50 (t, 1H), 7.20 (m, 2H), 7.15 (m, 1H), 7.02 br d, 1H), 4.80 (t, 1H), 2.90(m, 1H), 2.70 (m, 1H), 2.20 (m, 1H), 1.70 (m, 1H).

Sources & evidence

ORD record
ord-6526912a231e4273a9c8b881c2c4d2f5
Source dataset
uspto-grants-2010_04
Patent number
US07704995B2

Reaction notes

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