反应详情

A slurry of 2-amino-5-bromopyridine-3-carboxylic acid (7 g, 32.2 mmol) in methanol (150 mL) and H2SO4 (7 mmol) was heated to reflux for 48 h. The reaction mixture was concentrated to ca. 40 mL. Water (100 mmol) was added to the residual oil, and the mixture neutralized with sodium carbonate. Ethyl acetate (400 mL) was added and the organic layer was washed with saturated aqueous sodium chloride then dried (Na2SO4) and concentrated to give the title compound (5.5 g, 73.9% yield).

1. temperatureto reflux for 48 h
2. concentrationThe reaction mixture was concentrated to ca. 40 mL
3. washthe organic layer was washed with saturated aqueous sodium chloride
4. dry with materialthen dried (Na2SO4)
5. concentrationconcentrated