HCID 68650633, compound → HCID 59407593, compound

HRID 646728Notes

Reaction equation

HRID 646728 reaction equation
[OH:1][CH2:2][C:3]#[C:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C:10](=[O:14])[CH2:9][CH2:8]2>CO.[Pd]>[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C:10](=[O:14])[CH2:9][CH2:8]2

Participants

4

Reactant 1

HCID 68650633HCID 68650633, compound

Product 1

HCID 59407593HCID 59407593, compoundYield 94.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 5-(hydroxyprop-1-yn-1-yl)-2,3-dihydro-1H-indene-1-one (1.06 g, 5.71 mmol) in MeOH was added 10% Pd/C and hydrogenated by means of Pair shaker. After 12 h, the reaction mixture was filtered on Celite and concentrated in vacuo to give 5-(3-hydroxypropyl)-2,3-dihydro-1H-inden-1-one (1.03 g, 94% yield): MS (EI) for C12H14O2: 191.24 (MH+).

Workup

  1. filtrationthe reaction mixture was filtered on Celite
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-bc32c1a08c124fb9b06431b99bcd9024
Source dataset
uspto-grants-2010_04
Patent number
US07704995B2

Reaction notes

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