Bromine → HCID 131714841, compound

HRID 64674Notes

Reaction equation

HRID 64674 reaction equation
[Br:1][C:2]1[N:6]2[N:7]=[C:8]([Cl:11])[CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[CH3:12].[Br:13]Br>C(O)(=O)C>[Br-:1].[Br-:13].[Br:1][C:2]1[N:6]2[N:7]=[C:8]([Cl:11])[CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[CH3:12]

Participants

4

Reactant 2

HCID 24408BromineHCID 137121543-Bromo-6-chloro-2-methylimidazo[1,2-b]pyridazine

Product 1

HCID 131714841HCID 131714841, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

0.23 g (0.93 mMol) 3-bromo-6-chloro-2-methyl-imidazo[1,2-b]pyridazine obtained from Example 1 is dissolved in 2 ml concentrated acetic acid and treated with 1.39 mMol elemental bromine. From the reaction mixture crystallizes out after a little while 3-bromo-6-chloro-2-methyl-imidazo[1,2-b]pyridazine dibromide. This is filtered off and dried. Yield 0.38 g, (89.4%), M.pt 217°-220°.

Workup

  1. customFrom the reaction mixture crystallizes out after a little while 3-bromo-6-chloro-2-methyl-imidazo[1,2-b]pyridazine dibromide
  2. filtrationThis is filtered off
  3. customdried

Sources & evidence

ORD record
ord-da451269977943ada234786154e6e0cf
Source dataset
uspto-grants-1986_09
Patent number
US04609731

Reaction notes

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