反应详情

To a solution of 0.5 g of 3-(1-oxo-4-ethoxycarbonylbutyl)-N-(3-pyridyl)-indole in 25 ml of tetrahydrofuran is added 0.6 g of borane-tert-butylamine complex and 0.6 ml of glacial acetic acid. The reaction mixture is heated at 90° and monitored by high pressure liquid chromatography. When complete, the reaction mixture is evaporated under reduced pressure, water and methylene chloride are added, the pH is adjusted to 7-8 with sodium carbonate solution, the organic layer is separated, washed with water, dried and evaporated to dryness to yield 3-(4-ethoxycarbonylbutyl)-N-(3-pyridyl)-indole.

1. temperatureThe reaction mixture is heated at 90°
2. customWhen complete, the reaction mixture is evaporated under reduced pressure, water and methylene chloride
3. additionare added
4. customthe organic layer is separated
5. washwashed with water
6. customdried
7. customevaporated to dryness