1-Methylpiperazine → HCID 58638531, compound

HRID 646849Notes

Reaction equation

HRID 646849 reaction equation
[Cl:1][C:2]1[C:7](Cl)=[CH:6][C:5]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[C:4]([N+:15]([O-:17])=[O:16])[CH:3]=1.[CH3:18][N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[Cl:1][C:2]1[CH:3]=[C:4]([N+:15]([O-:17])=[O:16])[C:5]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:6][C:7]=1[N:22]1[CH2:23][CH2:24][N:19]([CH3:18])[CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 27742631-(4,5-dichloro-2-nitrophenyl)piperidine

Product 1

HCID 58638531HCID 58638531, compoundYield 84%

Procedure

The procedure of Example 5, step (b) was followed using 968 mg (3.52 mmol) of 1-(4,5-dichloro-2-nitro-phenyl)-piperidine (as prepared in the previous step) and 1.95 mL (17.6 mmol) of 1-methylpiperazine. Crystallization from hexane afforded 997 mg (84%) of the title compound as a yellow-tan solid: Mass spectrum (ESI, m/z): Calcd. for C16H23ClN4O2, 339.2 (M+H), found 339.1.

Workup

  1. customCrystallization from hexane

Sources & evidence

ORD record
ord-4859e666326a484389d406c78cfafdae
Source dataset
uspto-grants-2010_04
Patent number
US07705042B2

Reaction notes

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