HCID 68680769, compound → HCID 68683203, compound

HRID 646892Notes

Reaction equation

HRID 646892 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[C:16]([N:23]3[C:27]([CH3:28])=[CH:26][CH:25]=[C:24]3[CH3:29])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[C:16]([N:23]3[C:24]([CH3:29])=[CH:25][CH:26]=[C:27]3[CH3:28])[CH:15]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 68680769HCID 68680769, compound

Product 1

HCID 68683203HCID 68683203, compoundYield 101.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Using a procedure similar to Example 23, step (a), 4-[3-(2,5-dimethyl-pyrrol-1-yl)-4-nitro-phenyl]-piperazine-1-carboxylic acid tert-butyl ester (35 mg, 0.08 mmol) was stirred in MeOH in the presence of 5% Pd—C (20 mg) to afford 30 mg (100%) of the title compound as an oil. Mass spectrum (ESI, m/z): Calcd. for C21H30N4O2, 371.2 (M+H), found 371.1.

Sources & evidence

ORD record
ord-0d041ecb0e744490b3dc6d59bde83546
Source dataset
uspto-grants-2010_04
Patent number
US07705042B2

Reaction notes

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