反应详情

A mixture of 12.5 g. (0.05 mole) of 1-(1-naphthyloxy)-2-hydroxybutyl chloride and 14.5 g. (0.1 mole) of phenethylamine was heated at 120° C. for 20 min. on a hot plate. The resulting mixture was mixed with 250 ml. of acetone, heated to boiling and then filtered at room temperature. The filtrate was treated with 50 ml. of ethereal hydrogen chloride. The resulting white precipitate was filtered. The white crystalline solid was recrystallized from acetone and yielded 11.8 g. of the hydrochloride salt which melted at 163°-165° C.

1. additionA mixture of 12.5 g
2. additionThe resulting mixture was mixed with 250 ml
3. filtrationfiltered at room temperature
4. additionThe filtrate was treated with 50 ml
5. filtrationThe resulting white precipitate was filtered
6. customThe white crystalline solid was recrystallized from acetone
7. customyielded 11.8 g