4-Methoxybenzaldehyde → 82697-79-8

HRID 647069Notes

Reaction equation

HRID 647069 reaction equation
[CH:1](=O)[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.[SH:11][CH2:12][CH2:13][C:14]([NH2:16])=[O:15]>C1C=CC=CC=1>[CH3:9][O:8][C:5]1[CH:6]=[CH:7][C:2]([CH:1]2[S:11][CH2:12][CH2:13][C:14](=[O:15])[NH:16]2)=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 312444-MethoxybenzaldehydeHCID 69811Propanamide, 3-mercapto-

Product 1

HCID 306803882697-79-8Yield 94%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 13.6 g of p-anisaldehyde and 10.5 g of 3-mercaptopropionic acid amide in 150 ml of benzene was heated at 80° C. for 2 hours. The crystals which separated out after leaving the reaction mixture for a night were collected by filtration and recrystallized from hot benzene to obtain colourless minute aciculates melting at 185.5° to 186.5° C. in an amount of 21 g corresponding to a yield of 94%.

Workup

  1. customThe crystals which separated out
  2. customafter leaving the reaction mixture for a night
  3. filtrationwere collected by filtration
  4. customrecrystallized from hot benzene
  5. customto obtain colourless minute aciculates melting at 185.5° to 186.5° C. in an amount of 21 g corresponding to a yield of 94%

Sources & evidence

ORD record
ord-5da92e0aae824e3c8397d1652db8b2ad
Source dataset
uspto-grants-1983_10
Patent number
US04407799

Reaction notes

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