N-(4-phenyl-thiazol-2-yl)-oxamic acid → 2-Ethylthioethyl N-(4-phenyl-thiazol-2-yl)-oxamate

HRID 647123Notes

Reaction equation

[C:1]1([C:7]2[N:8]=[C:9]([NH:12][C:13](=[O:17])[C:14]([OH:16])=[O:15])[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:18]([S:20][CH:21](O)[CH3:22])[CH3:19]>>[C:1]1([C:7]2[N:8]=[C:9]([NH:12][C:13](=[O:17])[C:14]([O:16][CH2:19][CH2:18][S:20][CH2:21][CH3:22])=[O:15])[S:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

Reactant 2

HCID 4713520N-(4-phenyl-thiazol-2-yl)-oxamic acid

HCID 19024902Ethylthioethanol

Product 1

HCID 204856752-Ethylthioethyl N-(4-phenyl-thiazol-2-yl)-oxamate

Procedure

Using a method similar to Example 12, 6.2 g of N-(4-phenyl-thiazol-2-yl)-oxamic acid and 6.6 g of ethylthioethanol give, after crystallization of the product from ethanol, 3.4 g of the compound of the formula I, with R1 =C6H5 and R2 =CH2CH2SC2H5, of melting point 148°-149° C.

Workup

customgive
customafter crystallization of the product from ethanol, 3.4 g of the compound of the formula I

Sources & evidence

ORD record: ord-c24a988f795142e7a3c200ce844561a8
Source dataset: uspto-grants-1983_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04407810

Reaction notes

Loading…