4-Chlorophenyl isothiocyanate → HCID 13191291, compound

HRID 647130Notes

Reaction equation

HRID 647130 reaction equation
[F:1][CH:2]([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:14]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:13][NH:12][N:11]=2)=[CH:6][CH:5]=1.[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([N:29]=[C:30]=[S:31])=[CH:25][CH:24]=1>C(OCC)C>[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([NH:29][C:30]([N:12]2[CH2:13][CH:14]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:10]([C:7]3[CH:6]=[CH:5][C:4]([O:3][CH:2]([F:1])[F:21])=[CH:9][CH:8]=3)=[N:11]2)=[S:31])=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 164804-Chlorophenyl isothiocyanateHCID 13102610HCID 13102610, compound

Product 1

HCID 13191291HCID 13191291, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 5.8 g. of 3-(4-difluoromethoxyphenyl)-4-phenyl-2-pyrazoline and 3.4 g. of 4-chlorophenylisothiocyanate in 200 ml. of anhydrous ethyl ether was refluxed for 6 hours to react them. After cooling the reaction mixture, the precipitated crystal (6.1 g.) was separated by a filtration. It was confirmed that the product was 1-(4-chlorophenylthiocarbamoyl)-3-(4-difluoromethoxyphenyl)-4-phenyl-2-pyrazoline (melting point of 158.0°-161.0° C.) by the NMR spectrum.

Workup

  1. additionA mixture of 5.8 g
  2. customto react them
  3. temperatureAfter cooling the reaction mixture
  4. customthe precipitated crystal (6.1 g.) was separated by a filtration

Sources & evidence

ORD record
ord-7215355e89ad48d3846426d8fb9e2113
Source dataset
uspto-grants-1983_10
Patent number
US04407813

Reaction notes

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