Hydrochloric Acid → HCID 20485864, compound

HRID 647218Notes

Reaction equation

HRID 647218 reaction equation
O1C2C=CC=CC=2N=C1.[CH2:10]([N:28]([CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][CH2:65][CH2:66][CH2:67][CH2:68][CH3:69])[C:29](=[O:51])[C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([S:36](=[O:50])(=[O:49])[NH:37][C:38]2[CH:47]=[C:46]([OH:48])[C:41]3[N:42]=C(C)[O:44][C:40]=3[CH:39]=2)[CH:31]=1)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27].[ClH:70]>CO>[ClH:70].[NH2:42][C:41]1[C:46]([OH:48])=[CH:47][C:38]([NH:37][S:36]([C:32]2[CH:33]=[CH:34][CH:35]=[C:30]([C:29](=[O:51])[N:28]([CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][CH2:65][CH2:66][CH2:67][CH2:68][CH3:69])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH:31]=2)(=[O:50])=[O:49])=[CH:39][C:40]=1[OH:44]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 20485878HCID 20485878, compound

Product 1

HCID 20485864HCID 20485864, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of N,N-dioctadecyl-m-(2-methyl-4-hydroxy-6-benzoxazolylsulfamoyl)benzamide benzoxazole (17.3 g, 0.02 mole) in methanol (170 ml) was added hydrogen chloride gas. The mixture warmed, and complete solution resulted. Hydrogen chloride addition was continued until saturation had been achieved. The mixture was then refluxed for four hours, then allowed to stand at ambient temperature overnight. The resulting white precipitate was collected and dried to yield 15.3 g (88.4 percent). TLC showed the product to be pure.

Workup

  1. temperatureThe mixture warmed
  2. customcomplete solution resulted
  3. temperatureThe mixture was then refluxed for four hours
  4. customThe resulting white precipitate was collected
  5. customdried
  6. customto yield 15.3 g (88.4 percent)

Sources & evidence

ORD record
ord-d06023481e1748e09a87773f55353abe
Source dataset
uspto-grants-1983_10
Patent number
US04407930

Reaction notes

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