反应详情

To a stirred solution of 2-amino-5-nitro-p-cresol (3.3 g, 0.0146 mol) in xylene (35 ml) was added the triethylorthoacetate (6.4 g, 0.0392 mol) in one portion. The mixture was refluxed for one hour, filtered through a pad of decolorizing carbon and concentrated to dryness under reduced pressure. The residue was triturated with ligroin and 2.7 g (71 percent) of white solid was collected. NMR was consistent for the product.

1. temperatureThe mixture was refluxed for one hour
2. filtrationfiltered through a pad of decolorizing carbon
3. concentrationconcentrated to dryness under reduced pressure
4. customThe residue was triturated with ligroin and 2.7 g (71 percent) of white solid
5. customwas collected