反应详情

In a mixture of 2 ml of water and 2 ml of acetone is dissolved 0.26 g of sodium isovalerate, and 0.45 g of 16β-ethyl-17β-bromoacetoxy-4-estren-3-one and 10 ml of DMF are added to the above solution. The mixture is refluxed for 6 hours, and thereafter treated in the same manner as Example 26. The reaction mixture is then subjected to column chromatography. Following passage of 100 ml of diisopropyl ether-n-hexane (2:8), elution is carried out with 400 ml of a 1:1 mixture of the same solvents. The elutate is evaporated under reduced pressure to remove the solvent, giving 0.415 g of the above-identified compound as a colorless viscous oil.

1. additionare added to the above solution
2. temperatureThe mixture is refluxed for 6 hours
3. additiontreated in the same manner as Example 26
4. washpassage of 100 ml of diisopropyl ether-n-hexane (2:8), elution
5. additionis carried out with 400 ml of a 1:1 mixture of the same solvents
6. customThe elutate is evaporated under reduced pressure
7. customto remove the solvent