Sulfuric Acid → Sulfuric Acid

HRID 647368Notes

Reaction equation

HRID 647368 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3](=[O:16])[C:4](=[N:14][OH:15])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH3:13].[S:19](=[O:23])(=[O:22])([OH:21])[OH:20]>O>[S:19](=[O:21])(=[O:20])([OH:23])[OH:22].[OH:16][C:3]1([C:2]([F:17])([F:18])[F:1])[C:12]2[C:7](=[C:8]([CH3:13])[CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5][C:4]1=[N:14][OH:15]

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 714141471,1,1-Trifluoro-3-(hydroxyimino)-5-(2-methylphenyl)pentan-2-one

Product 2

HCID 1118Sulfuric AcidYield 50%HCID 731984713,4-dihydro-1-hydroxy-5-methyl-1-(trifluoromethyl)-2(1H)-naphthalenone oxime

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

cyclizing the 1,1,1-trifluoro-5-(2-methylphenyl)-2,3-pentanedione 3-oxime with 100% sulfuric acid or with aqueous sulfuric acid containing from 50 up to 100% by weight of sulfuric acid per volume of water, i.e. 50% up to 100% (w/v) aqueous sulfuric acid, to obtain 3,4-dihydro-1-hydroxy-5-methyl-1-(trifluoromethyl)-2(1H)-naphthalenone oxime;

Sources & evidence

ORD record
ord-a81c1560d5374488803fe8c54ec3bccc
Source dataset
uspto-grants-1983_10
Patent number
US04408077

Reaction notes

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