Sodium borohydride → HCID 13252420, compound

HRID 647405Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16](=[S:17])[C:15]3[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=3[C:9]2=[O:18])=[C:4]([F:19])[CH:3]=1.[BH4-].[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:16]([SH:17])[C:15]3[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=3[C:9]2=[O:18])=[C:4]([F:19])[CH:3]=1

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 20484937HCID 20484937, compound

Product 1

HCID 13252420HCID 13252420, compoundYield 81.2%

Procedure

By the same procedure as described in Method (a) of Example 1, 55.0 g of 2-(4-bromo-2-fluorophenyl)-2,3,4,5,6,7-hexahydro-3-thioxo-1H-isoindol-1-one was reduced with 18.0 g of sodium borohydride, thereby affording 44.9 g (yield of 81%) of the subject compound. Recrystallization from ethanol yielded white crystals, m.p. 87°-88° C.

Sources & evidence

ORD record: ord-3b033f10aa034289ade728507d9731f0
Source dataset: uspto-grants-1983_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04409018

Reaction notes

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