反应详情

In 15 ml of dioxane was dissolved 2.1 g of 2-(4-chloro-2-fluorophenyl)-2,3,4,5,6,7-hexahydro-3-mercapto-1H-isoindole-1-on, and 1.5 g of acrylonitrile, together with several drops of triethylamine, was added, followed by heating at 85° to 90° C. for 6 hours. The reaction solution was concentrated under reduced pressure, and the residual, oily substance was purified by means of column chromatography with the use of silica gel (acetone:hexane=1:3), thereby producing 1.5 g of the subject compound in white crystals, m.p. 101°-103° C.

1. temperatureby heating at 85° to 90° C. for 6 hours
2. concentrationThe reaction solution was concentrated under reduced pressure
3. customthe residual, oily substance was purified by means of column chromatography with the use of silica gel (acetone:hexane=1:3)