反应详情

In 30 ml of toluene were dissolved 3.0 g of 2-(4-chloro-2-fluorophenyl)-2,3,4,5,6,7-hexahydro-3-mercapto-1H-isoindol 1-one and 2.8 g of N-phenylthio-phthalimide, and the solution was heated under reflux for 3 hours. Upon cooling, there resulted crystals (phthalimide), which were filtered out, and the filtrate was concentrated under reduced pressure. A small amount of toluene was added and, upon standing overnight, there resulted crystals, which were collected by filtration and dried, thereby producing 2.7 g (yield of 67%) of the subject compound. Recrystallization from toluene yielded white crystals m.p. 127°-129° C.

1. temperaturethe solution was heated
2. temperatureunder reflux for 3 hours
3. temperatureUpon cooling