Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | P-Anisidine | HCID 7732 | — |
| Reactant | 1,3-Dichloroisoquinoline | HCID 298625 | — |
| Product | HCID 13386234 | HCID 13386234 | 18.4% |
Reaction Steps
A mixture of 1,3-dichloroisoquinoline (5.0 g; see Example 8) and p-anisidine (3.1 g) was heated at a temperature of 170° C. for a period of 2 hours. After cooling the product was purified by column chromatography over silica gel (eluant dichloromethane) to give 3-chloro-1-[N-(4-methoxyphenyl)amino]isoquinoline (1.32 g) mp 101° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04409017 |
|---|
| Source dataset | uspto-grants-1983_10 |
|---|
| ORD ID | ord-32e89c6b8c954f039638901f0a593eaf |
|---|
| Source note | uspto-grants-1983_10 |
|---|
