反应详情

2-{4-[N-(1,7-Dichloroisoquinolin-3-yl)-N-methylamino]phenoxy}propionyl chloride was prepared by adding phosphorus pentachloride (1.07 g) portionwise to a solution of 2-{4-[N-(1,7-dichloroisoquinolin-3-yl)-N-methylamino]phenoxy}propionic acid (2.0 g) in dichloromethane at room temperature and stirring the reaction mixture for a period of 12 hours.