Phosphorus pentachloride → HCID 20484914, compound

HRID 647435Notes

Reaction equation

HRID 647435 reaction equation
P(Cl)(Cl)(Cl)(Cl)[Cl:2].[Cl:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([Cl:18])[CH:16]=2)[CH:11]=[C:10]([N:19]([C:21]2[CH:32]=[CH:31][C:24]([O:25][CH:26]([CH3:30])[C:27]([OH:29])=O)=[CH:23][CH:22]=2)[CH3:20])[N:9]=1>ClCCl>[Cl:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([Cl:18])[CH:16]=2)[CH:11]=[C:10]([N:19]([C:21]2[CH:22]=[CH:23][C:24]([O:25][CH:26]([CH3:30])[C:27]([Cl:2])=[O:29])=[CH:31][CH:32]=2)[CH3:20])[N:9]=1

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 13386238HCID 13386238, compound

Product 1

HCID 20484914HCID 20484914, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-{4-[N-(1,7-Dichloroisoquinolin-3-yl)-N-methylamino]phenoxy}propionyl chloride was prepared by adding phosphorus pentachloride (1.07 g) portionwise to a solution of 2-{4-[N-(1,7-dichloroisoquinolin-3-yl)-N-methylamino]phenoxy}propionic acid (2.0 g) in dichloromethane at room temperature and stirring the reaction mixture for a period of 12 hours.

Sources & evidence

ORD record
ord-e8148651101645548af9ca87588e0b56
Source dataset
uspto-grants-1983_10
Patent number
US04409017

Reaction notes

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