Methyl iodide → HCID 86739058, compound

HRID 647440Notes

Reaction equation

HRID 647440 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([Cl:12])[CH:10]=2)[CH:5]=[C:4]([N:13]([C:15]2[CH:31]=[CH:30][C:18]([O:19][CH:20]([CH3:29])[C:21]([O:23][CH2:24][CH2:25]N(C)C)=[O:22])=[CH:17][CH:16]=2)[CH3:14])[N:3]=1.[CH3:32][I:33]>ClCCl>[CH3:32][I:33].[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([Cl:12])[CH:10]=2)[CH:5]=[C:4]([N:13]([C:15]2[CH:31]=[CH:30][C:18]([O:19][CH:20]([CH3:29])[C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:17][CH:16]=2)[CH3:14])[N:3]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 13386242HCID 13386242, compound

Product 1

HCID 86739058HCID 86739058, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 2-(dimethylamino)ethyl 2-{4-[N-(1,7-dichloroisoquinolin-3-yl)-N-methylamino]phenoxy}propionate in dichloromethane was added to a large excess of methyl iodide in dichloromethane. The mixture was stirred for 2 hrs at room temperature, then evaporated to give 2-dimethyl amino)ethyl 2-{4-[N-(1,7-dichloroisoquinolin-3-yl)-N-methylamino]phenoxy}propionate methyl iodide salt as yellow crystals mp 76° C.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-991afc3a61e0481d9411f0acf556fe4b
Source dataset
uspto-grants-1983_10
Patent number
US04409017

Reaction notes

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