Potassium Carbonate → HCID 20484903, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 2-bromo-2-methylpropionate (0.54 g), 4-[N-(1,7-dichloroisoquinolin-3-yl)-N-methylamino]phenol (0.74 g), potassium carbonate (0.38 g) dimethylformamide was heated at 100° C. for 28 hrs. The mixture was cooled, diluted with dichloromethane, washed with water and then dried over anhydrous magnesium sulfate. The solvent was evaporated to give an oil, which was purified by column chromatography over silica gel (eluent dichloromethane) to give ethyl 2-methyl-2-{4-[N-(1,7-dichloroisoquinolin-3-yl)-N-methylamino]-phenoxy}propionate (0.55 g) as a yellow oil.

Provenance & Evidence