反应详情

温度

100 °C

A mixture of ethyl 2-bromo-2-methylpropionate (0.54 g), 4-[N-(1,7-dichloroisoquinolin-3-yl)-N-methylamino]phenol (0.74 g), potassium carbonate (0.38 g) dimethylformamide was heated at 100° C. for 28 hrs. The mixture was cooled, diluted with dichloromethane, washed with water and then dried over anhydrous magnesium sulfate. The solvent was evaporated to give an oil, which was purified by column chromatography over silica gel (eluent dichloromethane) to give ethyl 2-methyl-2-{4-[N-(1,7-dichloroisoquinolin-3-yl)-N-methylamino]-phenoxy}propionate (0.55 g) as a yellow oil.

1. temperatureThe mixture was cooled
2. washwashed with water
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe solvent was evaporated
5. customto give an oil, which
6. customwas purified by column chromatography over silica gel (eluent dichloromethane)