HRID647459

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)CON=C(C(=O)O)c1csc(NC=O)n1

HCID54390951

未命名化合物

结构：COC1=C(C(=O)OCc2ccc([N+](=O)[O-])cc2)N2C(=O)C(N)[C@H]2SC1.Cl

HCID70362008

未命名化合物

PRODUCTS

生成物

结构：COC1=C(C(=O)OCc2ccc([N+](=O)[O-])cc2)N2C(=O)C(NC(=O)C(=NOCC(=O)OC(C)(C)C)c3csc(NC=O)n3)[C@H]2SC1

HCID131713135

未命名化合物

收率 100.4%

PROCEDURE

实验过程

4-Nitrobenzyl 7-amino-3-methoxy-3-cephem-4-carboxylate hydrochloride (4.02 g) and 2-(tert-butoxycarbonylmethoxyimino)-2-(2-formamidothiazol-4-yl)acetic acid (syn isomer, 3.62 g) were treated in a similar manner to to that of Example 1 to give 4-nitrobenzyl 7-[2-(tert-butoxycarbonylmethoxyimino)-2-(2-formamidothiazol-4-yl)acetamido]-3-methoxy-3-cephem-4-carboxylate (syn isomer, 6.8 g).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a23a21eb642246628b59fe1fa1139438
来源数据集: uspto-grants-1983_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04409217
来源说明: uspto-grants-1983_10

反应 SMILES

Cl.[NH2:2][CH:3]1[C:25](=[O:26])[N:5]2[C:6]([C:12]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=3)=[O:13])=[C:7]([O:10][CH3:11])[CH2:8][S:9][C@H:4]12.[C:27]([O:31][C:32]([CH2:34][O:35][N:36]=[C:37]([C:41]1[N:42]=[C:43]([NH:46][CH:47]=[O:48])[S:44][CH:45]=1)[C:38](O)=[O:39])=[O:33])([CH3:30])([CH3:29])[CH3:28]>>[C:27]([O:31][C:32]([CH2:34][O:35][N:36]=[C:37]([C:41]1[N:42]=[C:43]([NH:46][CH:47]=[O:48])[S:44][CH:45]=1)[C:38]([NH:2][CH:3]1[C:25](=[O:26])[N:5]2[C:6]([C:12]([O:14][CH2:15][C:16]3[CH:17]=[CH:18][C:19]([N+:22]([O-:24])=[O:23])=[CH:20][CH:21]=3)=[O:13])=[C:7]([O:10][CH3:11])[CH2:8][S:9][C@H:4]12)=[O:39])=[O:33])([CH3:30])([CH3:28])[CH3:29]