HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-t-Butoxycarbonylmethoxyimino-2-(2-formamidothiazol-4-yl)acetic acid → 4-Nitrobenzyl 7-[2-(tert-butoxycarbonylmethoxyimino)-2-(2-formamidothiazol-4-yl)acetamido]-3-methoxy-3-cephem-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-t-Butoxycarbonylmethoxyimino-2-(2-formamidothiazol-4-yl)acetic acid | HCID 54390951 | — |
| Reactant | 4-Nitrobenzyl 7-amino-3-methoxy-3-cephem-4-carboxylate hydrochloride | HCID 70362008 | — |
| Product | 4-Nitrobenzyl 7-[2-(tert-butoxycarbonylmethoxyimino)-2-(2-formamidothiazol-4-yl)acetamido]-3-methoxy-3-cephem-4-carboxylate | HCID 131713135 | 100.4% |
Reaction Steps
4-Nitrobenzyl 7-amino-3-methoxy-3-cephem-4-carboxylate hydrochloride (4.02 g) and 2-(tert-butoxycarbonylmethoxyimino)-2-(2-formamidothiazol-4-yl)acetic acid (syn isomer, 3.62 g) were treated in a similar manner to to that of Example 1 to give 4-nitrobenzyl 7-[2-(tert-butoxycarbonylmethoxyimino)-2-(2-formamidothiazol-4-yl)acetamido]-3-methoxy-3-cephem-4-carboxylate (syn isomer, 6.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04409217 |
| Source dataset | uspto-grants-1983_10 |
| ORD ID | ord-a23a21eb642246628b59fe1fa1139438 |
| Source note | uspto-grants-1983_10 |