Aminoacetamidine Dihydrobromide → 2-Amino-7-acetyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine

HRID 647472Notes

Reaction equation

HRID 647472 reaction equation
[C:1]([N:4]1[CH2:10][CH2:9][C:8](=O)[C:7](=O)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].C(N1CCCC(=O)C(=O)C1)(=O)C.Br.Br.[NH2:27][CH2:28][C:29]([NH2:31])=[NH:30]>>[NH2:31][C:29]1[CH:28]=[N:27][C:8]2[CH2:9][CH2:10][N:4]([C:1](=[O:3])[CH3:2])[CH2:5][CH2:6][C:7]=2[N:30]=1

Participants

4

Reactant 3

HCID 16211382Aminoacetamidine DihydrobromideHCID 204364421-Acetyl-hexahydroazepine-3,4-dioneHCID 204850321-Acetyl-hexahydroazepine-4,5-dione

Product 1

HCID 130370432-Amino-7-acetyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine

Procedure

This compound was prepared analogous to Example 13 by reacting a mixture of 1-acetyl-hexahydroazepine-4,5-dione and 1-acetyl-hexahydroazepine-3,4-dione (prepared from 1-acetylhexhydroazepine-4-ones by selenium dioxide oxidation in dioxane/water) with 2-amino-acetamidine dihydrobromide.

Workup

  1. customThis compound was prepared analogous to Example 13

Sources & evidence

ORD record
ord-06b9fec509c543c0b17bd18ab19b07e5
Source dataset
uspto-grants-1983_10
Patent number
US04409220

Reaction notes

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