Hydrochloric Acid → 2-Amino-7-ethyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine monohydrochloride

HRID 647476Notes

Reaction equation

HRID 647476 reaction equation
[C:1]([N:4]1[CH2:10][CH2:9][C:8]2[N:11]=[CH:12][C:13]([NH2:15])=[N:14][C:7]=2[CH2:6][CH2:5]1)(=O)[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].[ClH:22]>>[ClH:22].[NH2:15][C:13]1[CH:12]=[N:11][C:8]2[CH2:9][CH2:10][N:4]([CH2:1][CH3:2])[CH2:5][CH2:6][C:7]=2[N:14]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 130370432-Amino-7-acetyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepineHCID 21226445Aluminium lithium hydride

Product 1

HCID 204364062-Amino-7-ethyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine monohydrochloride

Procedure

This compound was prepared analogous to Example 17 from 7-acetyl-2-amino-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine by reduction with lithium aluminum hydride and subsequent precipitation of the monohydrochloride.

Sources & evidence

ORD record
ord-f8d9a552c2a448768a5a853f1de884a3
Source dataset
uspto-grants-1983_10
Patent number
US04409220

Reaction notes

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