Hydroxylamine → 2-Amino-7-ethyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine

HRID 647489Notes

Reaction equation

Br.[CH2:2]([N:4]1[CH2:10][CH2:9][CH:8](Br)[C:7](=O)[CH2:6][CH2:5]1)[CH3:3].[NH2:13]O.Cl.[NH2:16][CH2:17][C:18]#[N:19]>>[NH2:19][C:18]1[CH:17]=[N:16][C:8]2[CH2:9][CH2:10][N:4]([CH2:2][CH3:3])[CH2:5][CH2:6][C:7]=2[N:13]=1

Participants

Reactant 3

HCID 787Hydroxylamine

HCID 11491918Aminoacetonitrile hydrochloride

HCID 204364081-Ethyl-5-bromo-hexahydro-azepin-4-one hydrobromide

Product 1

HCID 30678372-Amino-7-ethyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine

Procedure

This compound was prepared analogous to Example 40 from 1-ethyl-5-bromo-hexahydro-azepin-4-one hydrobromide, hydroxylamine and α-amino-acetonitrile hydrochloride.

Sources & evidence

ORD record: ord-855967ab3aff49b3be4192abfc594a0c
Source dataset: uspto-grants-1983_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04409220

Reaction notes

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