反应详情

温度

70 °C

11.65 g of 20A was mixed with 13.8 g of phosphorus pentachloride, and the mixture was slowly heated to ca. 70° C., when vigorous reaction occurred. When reaction had subsided, heating was continued until evolution of hydrogen chloride ceased (about 1 hour), after which phosphoryl chloride was removed in vacuo, and the residue chromatographically purified to yield 1-phenyl-4-ethoxycarbonyl-5-chloro-1,2,3-triazole (20B), as a solid, m.p.: 80°-81° C.

1. customwhen vigorous reaction
2. customWhen reaction
3. temperatureheating
4. custom(about 1 hour)
5. customafter which phosphoryl chloride was removed in vacuo
6. customthe residue chromatographically purified