Picolyl chloride hydrochloride → 2-{[(2-Ethyl-1,8-dioxaspiro[4.5]decan-2-yl)methoxy]methyl}pyridine

Participants

Role	Name	HCID	Charge
Reactant	Picolyl chloride hydrochloride	HCID 23392	—
Reactant	Sodium hydride	HCID 24758	—
Reactant	(2-Ethyl-1,8-dioxaspiro[4.5]decan-2-yl)methanol	HCID 13237164	—
Product	2-{[(2-Ethyl-1,8-dioxaspiro[4.5]decan-2-yl)methoxy]methyl}pyridine	HCID 13237166	62.5%

Reaction Steps

Following procedures similar to Embodiments XVII-XIX, 1.10 g of 2-ethyl-1,8-dioxaspiro[4.5]decane-2-methanol was treated with 1.35 g of 2-picolinyl chloride hydrochloride in the presence of sodium hydride to yield 1.00 g of the desired product as pale yellow liquid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04410354
Source dataset	uspto-grants-1983_10
ORD ID	ord-81f8fe30c2164a7eb07decb167610301
Source note	uspto-grants-1983_10