Methanethiol → HCID 20483194, compound

HRID 647764Notes

Reaction equation

HRID 647764 reaction equation
[Na].[CH3:2][SH:3].Cl[CH2:5][CH2:6][CH2:7][N:8]([CH:12]1[CH2:21][CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][C:18]=2[O:22][CH3:23])[CH2:13]1)[CH2:9][CH2:10][CH3:11]>C(O)C>[CH3:23][O:22][C:18]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:19]=1[CH2:20][CH2:21][CH:12]([N:8]([CH2:7][CH2:6][CH2:5][S:3][CH3:2])[CH2:9][CH2:10][CH3:11])[CH2:13]2

Participants

5

Reactant 3

HCID 878MethanethiolHCID 5360545SodiumHCID 20483193HCID 20483193, compound

Product 1

HCID 20483194HCID 20483194, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent3×

Procedure

2.35 g sodium are dissolved in 50 ml absolute ethanol and immediately 4.8 g methylmercaptan in 60 ml ethanol are added dropwise. The mixture is warmed to 45° and at this temperature a solution of 19.7 g 2-[N-(3-chloropropyl)-N-propylamino]-1,2,3,4-tetrahydro-5-methoxynaphthalene in 120 ml absolute ethanol are added. The mixture is stirred at 50° for 1 hour. The residue is partitioned between ether and water. The ether phase is dried over potassium carbonate, filtered and concentrated. The resultant oil containing the heading compound is used further as such.

Workup

  1. additionare added
  2. customThe residue is partitioned between ether and water
  3. dry with materialThe ether phase is dried over potassium carbonate
  4. filtrationfiltered
  5. concentrationconcentrated
  6. additionThe resultant oil containing the heading compound

Sources & evidence

ORD record
ord-e5a3fcfc6f244834a015a0f54ae6d972
Source dataset
uspto-grants-1983_10
Patent number
US04410519

Reaction notes

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