Mitoxantrone → HCID 20483291, compound

HRID 647785Notes

Reaction equation

HRID 647785 reaction equation
[OH:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[C:9]([NH:24][CH2:25][CH2:26][NH:27][CH2:28][CH2:29][OH:30])[CH:10]=[CH:11][C:12]=3[NH:17][CH2:18][CH2:19][NH:20][CH2:21][CH2:22][OH:23])[C:7](=[O:31])[C:6]=2[C:5]([OH:32])=[CH:4][CH:3]=1.[NH:33]1[CH:37]=[CH:36][CH:35]=[C:34]1[CH:38]=O>C1(C)C=CC=CC=1>[OH:32][C:5]1[C:6]2[C:7](=[O:31])[C:8]3[C:13](=[C:12]([NH:17][CH2:18][CH2:19][N:20]4[CH2:21][CH2:22][O:23][CH:38]4[C:34]4[NH:33][CH:37]=[CH:36][CH:35]=4)[CH:11]=[CH:10][C:9]=3[NH:24][CH2:25][CH2:26][N:27]3[CH2:28][CH2:29][O:30][CH:38]3[C:34]3[NH:33][CH:37]=[CH:36][CH:35]=3)[C:14](=[O:16])[C:15]=2[C:2]([OH:1])=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 4212MitoxantroneHCID 13854Pyrrole-2-carboxaldehyde

Product 1

HCID 20483291HCID 20483291, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A suspension of 3.11 g. of 1,4-dihydroxy-5,8-bis[[2-(2-hydroxyethylamino)ethyl]amino]anthraquinone [prepared as described in Example 1(A)] in 55 ml. of toluene containing 2.0 g. of pyrrole-2-carboxaldehyde is stirred and refluxed as for Example 1(B). The hot solution is filtered. The filtrate is concentrated and allowed to stand at room temperature. The title compound separates as blue-black crystals.

Workup

  1. additionA suspension of 3.11 g
  2. temperaturerefluxed as for Example 1(B)
  3. filtrationThe hot solution is filtered
  4. concentrationThe filtrate is concentrated
  5. customto stand at room temperature

Sources & evidence

ORD record
ord-8130487a994e49549e96d5bb35a1d2df
Source dataset
uspto-grants-1983_10
Patent number
US04410524

Reaction notes

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