反应详情

2.75 g (9.3 millimoles) of 3-[p-(1-chlorocyclopropylcarbonylamino)-benzoyl]-propionic acid, 0.47 g (9.4 millimoles) of hydrazine hydrate and 20 ml of ethanol are refluxed for 6 hours. The product is filtered off at 10° C., washed with ethanol and dried under reduced pressure at 50° C., giving 2.5 g (92% of theory) of 6-[p-(1-chlorocyclopropylcarbonylamino)-phenyl]-4,5-dihydro-3(2H)-pyridazinone as colorless crystals (identical with the compound from Example 7).

1. filtrationThe product is filtered off at 10° C.
2. washwashed with ethanol
3. customdried under reduced pressure at 50° C.