Phosgene → HCID 14209981, compound

HRID 647817Notes

Reaction equation

HRID 647817 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]2[C:11]=1[C:10](=[O:12])[NH:9][C:8]1[CH:13]=[CH:14][CH:15]=[CH:16][C:7]=1[NH:6]2.[C:17](Cl)([Cl:19])=[O:18]>O1CCOCC1.C1(C)C=CC=CC=1>[Cl:19][C:17]([N:6]1[C:7]2[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=2[NH:9][C:10](=[O:12])[C:11]2=[C:2]([CH3:1])[S:3][CH:4]=[C:5]12)=[O:18]

Participants

5

Reactant 2

HCID 6371PhosgeneHCID 12658724HCID 12658724, compound

Product 1

HCID 14209981HCID 14209981, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 312751,4-DioxaneSolvent

Procedure

From 4,9-dihydro-1-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and phosgene in a mixture of dioxane and toluene, 4-chlorocarbonyl-4,9-dihydro-1-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one was obtained, m.p. 235°-236° C. (chloroform);

Sources & evidence

ORD record
ord-6b5e22710614478d84cc944b3b95b3b8
Source dataset
uspto-grants-1983_10
Patent number
US04410527

Reaction notes

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