Sodium borohydride → HCID 178512085, compound

HRID 647820Notes

Reaction equation

HRID 647820 reaction equation
[BH4-].[Na+].[CH2:3]1[O:11][C:10]2[CH:9]=[CH:8][C:7]([C:12](=[O:32])[CH2:13][N:14]3[CH2:19][CH2:18][CH:17]([N:20]4[C:24]5[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=5[NH:22][C:21]4=[N:29][C:30]#[N:31])[CH2:16][CH2:15]3)=[CH:6][C:5]=2[O:4]1>C(O)C>[CH2:3]1[O:11][C:10]2[CH:9]=[CH:8][C:7]([CH:12]([OH:32])[CH2:13][N:14]3[CH2:19][CH2:18][CH:17]([N:20]4[C:24]5[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=5[NH:22][C:21]4=[N:29][C:30]#[N:31])[CH2:16][CH2:15]3)=[CH:6][C:5]=2[O:4]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 178512084HCID 178512084, compound

Product 1

HCID 178512085HCID 178512085, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In this example, 600 mg of sodium borohydride is added to a suspension of 715 mg of the product obtained in Example 9 in 30 ml of ethanol at room temperature. After completion of the addition, the reaction mixture is concentrated. The residue is mixed with water, and the crystals deposited are separated by filtration and dried. The crude crystals are recrystallized from methanol to obtain 632 mg of the desired product.

Workup

  1. additionAfter completion of the addition
  2. concentrationthe reaction mixture is concentrated
  3. additionThe residue is mixed with water
  4. customthe crystals deposited are separated by filtration
  5. customdried
  6. customThe crude crystals are recrystallized from methanol

Sources & evidence

ORD record
ord-3061a33aaa9642f4b6ff5fbfe272ae88
Source dataset
uspto-grants-1983_10
Patent number
US04410528

Reaction notes

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