Veratrole → 4-(3,4-Dimethoxybenzoyl)-5-ethyl-2-imidazolidinone

HRID 647832Notes

Reaction equation

HRID 647832 reaction equation
[CH2:1]([CH:3]1[CH:7]([C:8]([OH:10])=O)[NH:6][C:5](=[O:11])[NH:4]1)[CH3:2].[CH3:12][O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[O:20][CH3:21]>>[CH3:12][O:13][C:14]1[CH:19]=[C:18]([CH:17]=[CH:16][C:15]=1[O:20][CH3:21])[C:8]([CH:7]1[CH:3]([CH2:1][CH3:2])[NH:4][C:5](=[O:11])[NH:6]1)=[O:10]

Participants

3

Reactant 2

HCID 7043VeratroleHCID 13245335HCID 13245335, compound

Product 1

HCID 132453364-(3,4-Dimethoxybenzoyl)-5-ethyl-2-imidazolidinone

Conditions

Temperature
100 °C

Procedure

In 100 g PPA are suspended 15.8 g 4-ethyl-2-oxoimidazolidine-5-carboxylic acid and 13.8 g 1,2-dimethoxybenzene. The mixture is rapidly stirred and heated for 5 hours at 100° C. The reaction mixture is quenched with water and the product separates as a solid. The solid is collected and washed with water and dried. Purification is effected by chromatography over silica gel.

Workup

  1. customThe reaction mixture is quenched with water
  2. customThe solid is collected
  3. washwashed with water
  4. customdried
  5. customPurification

Sources & evidence

ORD record
ord-fa1bad0c5c654454b1385555b3940788
Source dataset
uspto-grants-1983_10
Patent number
US04410540

Reaction notes

Loading…