反应详情

温度

0 °C

5-(2-Formyl-3-hydroxyphenoxy)pentanoic acid (119 mg, 0.5 mM) was dissolved in ethyl acetate (5 ml) and cooled to 0° C. under nitrogen with stirring. Dicyclohexylamine (0.11 ml, 100 mg, 0.55 mM) was then added and the mixture stirred at 0° C. (1/2 hr) under nitrogen. The precipitated solid was then filtered off and washed with ethyl acetate to give dicyclohexylammonium 5-(2-formyl-3-hydroxyphenoxy)pentanoate, 0.25 hydrate, m.p. 114°-115° C.

1. stirringthe mixture stirred at 0° C. (1/2 hr) under nitrogen
2. filtrationThe precipitated solid was then filtered off
3. washwashed with ethyl acetate