Piperonylamine → HCID 20484278, compound

HRID 647933Notes

Reaction equation

HRID 647933 reaction equation
Cl.[CH2:2]([O:9][C:10]([C:12]1[S:13][C:14]2[CH:21]=[CH:20][C:19]([NH:22]N)=[CH:18][C:15]=2[C:16]=1[CH3:17])=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.O.Cl.[NH:26]1[CH2:31][CH2:30][C:29](=O)[CH2:28][CH2:27]1>C(O)(C)C>[CH2:2]([O:9][C:10]([C:12]1[S:13][C:14]2[C:15](=[C:18]3[C:19](=[CH:20][CH:21]=2)[NH:22][C:29]2[CH2:30][CH2:31][NH:26][CH2:27][C:28]3=2)[C:16]=1[CH3:17])=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 2723901PiperonylamineHCID 70531542HCID 70531542, compound

Product 1

HCID 20484278HCID 20484278, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

1 g of 5-hydrazino-3-methylbenzothiophene-2-carboxylic acid benzyl ester hydrochloride and 1 g of 4-piperidone hydrochloride monohydrate are boiled in 50 ml of isopropanol under N2 for 10 hours. The solvent is then evaporated off, the residue is suspended in water and the aqueous suspension is rendered alkaline with KHCO3 and extracted with ethyl acetate; the extract is washed, dried and evaporated and the residue is recrystallised from isopropanol. Melting point 178° C.

Workup

  1. customThe solvent is then evaporated off
  2. extractionextracted with ethyl acetate
  3. washthe extract is washed
  4. customdried
  5. customevaporated
  6. customthe residue is recrystallised from isopropanol

Sources & evidence

ORD record
ord-5792ba4b124d4d62b47337948800ea5a
Source dataset
uspto-grants-1983_10
Patent number
US04410536

Reaction notes

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